Advances in the field of tissue engineering are increasingly reliant on biomaterials that instruct, rather than simply permit, a desired cellular response. Craniofacial bone defects are common in the context of congenital, traumatic, and post-oncologic conditions. Such bone defects are often large in size and heal poorly, motivating regenerative medicine efforts. A particular barrier to regenerative healing is the significant immune and inflammatory response post injury which can inhibit cell recruitment, vascular remodeling, and new tissue biosynthesis. My laboratory is developing a class of mineralized collagen biomaterial capable of meeting a wide range of design requirements for successful deployment into CMF bone defects, notably the ability to conformally fit complex defect geometries and support stem cell osteogenesis. My research aims to understand the effect of scaffold biophysical properties (microstructure, stiffness, alignment, mineral morphology) on the recruitment and subsequent activation status of macrophages. My ultimate goal is to demonstrate biomaterials capable of modulating the kinetics of the macrophage response post injury as a means to accelerate implant integration and subsequent bone regeneration.