Table of Contents


Modulating Temporospatial Phosphate Equilibrium by Nanoparticulate Mineralized Collagen Materials Induces Osteogenesis via PiT-1 and PiT-2
Ren, Xiaoyan; Zhou, Qi; Bedar, Meiwand; Foulad, David; Huang, Kelly X; Dejam, Dillon; Dahan, Natalie J; Kolliopoulos, Vasiliki; Harley, Brendan A C; Lee, Justine C
Adv Healthc Mater. 2023, DOI:

Osteoprotegerin-eluting nanoparticulate mineralized collagen scaffolds improve skull regeneration
Ren, Xiaoyan; Dejam, Dillon; Oberoi, Michelle K; Dahan, Natalie J; Zhou, Qi; Huang, Kelly X; Bedar, Meiwand; Chan, Candace H; Kolliopoulos, Vasiliki; Dewey, Marley J; Harley, Brendan A C; Lee, Justine C
Biomater Adv. 2023, 145, 213262.

Hydrolysis-Resistant Ester-Based Linkers for Development of Activity-Based NIR Bioluminescence Probes
Yadav, Anuj K; Zhao, Zhenxiang; Weng, Yourong; Gardner, Sarah H; Brady, Catharine J; Pichardo Peguero, Oliver D; Chan, Jefferson
J Am Chem Soc. 2023, 145, 1460-1469.

Substrate Specificity of the Flavoenzyme BhaC1 That Converts a C-Terminal Trp to a Hydroxyquinone
Daniels, Page N; van der Donk, Wilfred A
Biochemistry. 2023, 62, 378-387.


Interface between Two Immiscible Electrolyte Solutions Electrodes for Chemical Analysis
Jetmore, Henry David; Anupriya, Edappalil Satheesan; Cress, Tanner Joe; Shen, Mei
Anal Chem. 2022, 94, 16519-16527.

High throughput analysis of vacuolar acidification
Zhang, Chi; Balutowski, Adam; Feng, Yilin; Calderin, Jorge D; Fratti, Rutilio A
Anal Biochem. 2022, 658, 114927.

The interdependent transport of yeast vacuole Ca2+ and H+ and the role of phosphatidylinositol 3,5-bisphosphate
Zhang, Chi; Feng, Yilin; Balutowski, Adam; Miner, Gregory E; Rivera-Kohr, David A; Hrabak, Michael R; Sullivan, Katherine D; Guo, Annie; Calderin, Jorge D; Fratti, Rutilio A
J Biol Chem. 2022, 298, 102672.

Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis
Rice, Andrew J; Pelton, Jarrett M; Kramer, Nicholas J; Catlin, Daniel S; Nair, Satish K; Pogorelov, Taras V; Mitchell, Douglas A; Bowers, Albert A
J Am Chem Soc. 2022, 144, 21116–21124.

Synthetic Platforms for Characterizing and Targeting of SARS-CoV-2 Genome Capping Enzymes
Ornelas, Marya Y; Thomas, Angela Y; Johnson Rosas, L Idalee; Scoville, Riley O; Mehta, Angad P
ACS Synth Biol. 2022, 11, 3759-3771.

Amnion and chorion matrix maintain hMSC osteogenic response and enhance immunomodulatory and angiogenic potential in a mineralized collagen scaffold
Kolliopoulos, Vasiliki; Dewey, Marley J; Polanek, Maxwell; Xu, Hui; Harley, Brendan A C
Front Bioeng Biotechnol. 2022, 10, 1034701.

The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer
Nelczyk, Adam T; Ma, Liqian; Gupta, Anasuya Das; Gamage, Hashni Epa Vidana; McHenry, Michael T; Henn, Madeline A; Kadiri, Mohammed; Wang, Yu; Krawczynska, Natalia; Bendre, Shruti; He, Sisi; Shahoei, Sayyed Hamed; Madak-Erdogan, Zeynep; Hsiao, Shih-Hsuan; Saleh, Tareq; Carpenter, Valerie; Gewirtz, David A; Spinella, Michael J; Nelson, Erik R
Biochim Biophys Acta Mol Basis Dis. 2022, 1868, 166515.

Depth Correction of 3D NanoSIMS Images Shows Intracellular Lipid and Cholesterol Distributions while Capturing the Effects of Differential Sputter Rate
Brunet, Melanie A; Gorman, Brittney L; Kraft, Mary L
ACS Nano. 2022, 16, 16221-16233.

A scalable platform to discover antimicrobials of ribosomal origin
Ayikpoe, Richard S; Shi, Chengyou; Battiste, Alexander J; Eslami, Sara M; Ramesh, Sangeetha; Simon, Max A; Bothwell, Ian R; Lee, Hyunji; Rice, Andrew J; Ren, Hengqian; Tian, Qiqi; Harris, Lonnie A; Sarksian, Raymond; Zhu, Lingyang; Frerk, Autumn M; Precord, Timothy W; van der Donk, Wilfred A; Mitchell, Douglas A; Zhao, Huimin
Nat Commun. 2022, 13, 6135.

Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases
Miller, Justin C; Schuler, Mary A
J Biol Chem. 2022, 298, 102237.

Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy
Kelly, Aya M; Berry, Matthew R; Tasker, Sarah Z; McKee, Sydney A; Fan, Timothy M; Hergenrother, Paul J
J Am Chem Soc. 2022, 144, 12367-12380.

The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells
Ma, Liqian; Vidana Gamage, Hashni Epa; Tiwari, Srishti; Han, Chaeyeon; Henn, Madeline A; Krawczynska, Natalia; Dibaeinia, Payam; Koelwyn, Graeme J; Das Gupta, Anasuya; Bautista Rivas, Rafael Ovidio; Wright, Chris L; Xu, Fangxiu; Moore, Kathryn J; Sinha, Saurabh; Nelson, Erik R
Endocrinology. 2022, 163, DOI:

Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway
Nguyen, Dinh T; Le, Tung T; Rice, Andrew J; Hudson, Graham A; van der Donk, Wilfred A; Mitchell, Douglas A
J Am Chem Soc. 2022, 144, 11263-11269

Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity
Boudreau, Matthew W; Hergenrother, Paul J
RSC Med. Chem. 2022, 13, 711-725.

Recent Advances in Machine Learning Variant Effect Prediction Tools for Protein Engineering
Horne, Jesse; Shukla, Diwakar
Ind. Eng. Chem. Res. 2022, 61, 6235-6245.

Radical SAM Enzymes and the Unexplored Chemistry of RiPP Biosynthesis
Precord, Timothy; Hudson, Graham; Mahanta, Nilkamal; Mitchell, Douglas; Gerlt, John
The Faseb Journal. 2022, in press published on web May 13, 2022

Integration of machine learning with computational structural biology of plants
Chen, Jiming; Shukla, Diwakar
Biochem J. 2022, 479, 921-928.

Activation Mechanism of Strigolactone Receptors and Its Impact on Ligand Selectivity between Host and Parasitic Plants
Chen, Jiming; Nelson, David C; Shukla, Diwakar
J. Chem. Inf. Model. 2022, 62, 1712–1722.

Tissue-specific alternative splicing separates the catalytic and cell signaling functions of human leucyl-tRNA synthetase
Baymiller, Max; Nordick, Benjamin; Forsyth, Connor M.; Martinis, Susan A
J. Biol. Chem. 2022, 298, 101757.

Dual Role of Strigolactone Receptor Signaling Partner in Inhibiting Substrate Hydrolysis
Sobecks, Briana L; Chen, Jiming; Shukla, Diwakar
J. Phys. Chem. B. 2022, 126, 2188-2195.

Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer
Boudreau, Matthew W; Mulligan, Michael P; Shapiro, David J; Svec, Riley L; Fan, Timothy M; Hergenrother, Paul J
J. Med. Chem. 2022, 65, 3894-3912.

Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture
Svec, Riley L; McKee, Sydney A; Berry, Matthew R; Kelly, Aya M; Fan, Timothy M.; Hergenrother, Paul J
ACS Chem. Biol. 2022, 17, 299-313.

A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor
Daniels, Page N; Lee, Hyunji; Splain, Rebecca A; Ting, Chi P; Zhu, Lingyang; Zhao, Xiling; Moore, Bradley S; van der Donk, Wilfred A
Nat. Chem. 2022, 14, 71-77.


Structural and mechanistic investigations of protein S-glycosyltransferases
Fujinami, Daisuke; Garcia de Gonzalo, Chantal V; Biswas, Subhanip; Hao, Yue; Wang, Huan; Garg, Neha; Lukk, Tiit; Nair, Satish K; van der Donk, Wilfred A
Cell Chem. Biol. 2021, 28, 1740-1749.

Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer
Ziegler, Yvonne; Guillen, Valeria Sanabria; Kim, Sung Hoon; Katzenellenbogen, John A; Katzenellenbogen, Benita S
Cancers (Basel). 2021, 13, 6282.

Insertion-trigger residues differentially modulate endosomal escape by cytotoxic necrotizing factor toxins
Haywood, Elizabeth E; Handy, Nicholas B; Lopez, James W; Ho, Mengfei; Wilson, Brenda A
J. Biol. Chem. 2021, 297, 101347.

Thienylpiperidine Donor NIR Xanthene-Based Dye for Photoacoustic Imaging
Rathnamalala, Chathuranga S L; Pino, Nicholas W; Herring, Bailey S; Hooper, Mattea; Gwaltney, Steven R; Chan, Jefferson; Scott, Colleen N
Org. Lett. 2021, 23, 7640-7644.

Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients
Tonogai, Emily J; Huang, Shan; Botham, Rachel C; Berry, Matthew R; Joslyn, Stephen K; Daniel, Gregory B; Chen, Zixin; Rao, Jianghong; Zhang, Xiang; Basuli, Falguni; Rossmeisl, John H; Riggins, Gregory J; LeBlanc, Amy K; Fan, Timothy M; Hergenrother, Paul J
Neuro. Oncol. 2021, 23, 1723-1735.

Role of substrate recognition in modulating strigolactone receptor selectivity in witchweed
Chen, Jiming; White, Alexandra; Nelson, David C; Shukla, Diwakar
J. Biol. Chem. 2021, 297, 101092.

Dual-mechanism estrogen receptor inhibitors
Min, Jian; Nwachukwu, Jerome C; Min, Charles K; Njeri, Jacqline W; Srinivasan, Sathish; Rangarajan, Erumbi S; Nettles, Charles C; Sanabria Guillen, Valeria; Ziegler, Yvonne; Yan, Shunchao; Carlson, Kathryn E; Hou, Yingwei; Kim, Sung Hoon; Novick, Scott; Pascal, Bruce D; Houtman, Rene; Griffin, Patrick R; Izard, Tina; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Nettles, Kendall W
Proc. Natl. Acad. Sci. 2021, 118, e2101657118

A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing
Gardner, Sarah H; Brady, Catharine J; Keeton, Cameron; Yadav, Anuj K; Mallojjala, Sharath C; Lucero, Melissa Y; Su, Shengzhang; Yu, Zhengxin; Hirschi, Jennifer S; Mirica, Liviu M; Chan, Jefferson
Angew Chem Int Ed Engl. 2021, 60, 18860-18866.

Structure-Activity Relationships of the Enterococcal Cytolysin
Rahman, Imran R; Sanchez, Alondra; Tang, Weixin; van der Donk, Wilfred A
ACS Infect. Dis. 2021, 7, 2445-2454.

Depth correction of 3D NanoSIMS images using secondary electron pixel intensities
Gorman, Brittney L; Brunet, Melanie A; Kraft, Mary L
Biointerphases. 2021, 16, 41005.

Glycosaminoglycan content of a mineralized collagen scaffold promotes mesenchymal stem cell secretion of factors to modulate angiogenesis and monocyte differentiation
Dewey, Marley J; Kolliopoulos, Vasiliki; Ngo, Mai T; Harley, Brendan A C
Materialia (Oxf). 2021, 18, 101149.

Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy
Lundberg, Alycen P; Boudreau, Matthew W; Selting, Kim A; Chatkewitz, Lindsay E; Samuelson, Jonathan; Francis, Joshua M; Parkinson, Elizabeth I; Barger, Anne M; Hergenrother, Paul J; Fan, Timothy M
Neoplasia. 2021, 23, 811-822.

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice
Boudreau, Matthew W; Duraki, Darjan; Wang, Lawrence; Mao, Chengjian; Kim, Ji Eun; Henn, Madeline A; Tang, Bingtao; Fanning, Sean W; Kiefer, Jeffrey; Tarasow, Theodore M; Bruckheimer, Elizabeth M; Moreno, Ramon; Mousses, Spyro; Greene, Geoffrey L; Roy, Edward J; Park, Ben Ho; Fan, Timothy M; Nelson, Erik R; Hergenrother, Paul J; Shapiro, David J
Sci. Transl. Med. 2021, 13, eabf1383

Unbiased proteomic screening identifies a novel role for the E3 ubiquitin ligase Nedd4-2 in translational suppression during ER stress
Eagleman, Daphne E; Zhu, Jiuhe; Liu, Dai-Chi; Seimetz, Joseph; Kalsotra, Auinash; Tsai, Nien-Pei
J. Neurochem. 2021, 157, 1809-1820.

Development of NIR-II Photoacoustic Probes Tailored for Deep-Tissue Sensing of Nitric Oxide
Lucero, Melissa Y; East, Amanda K; Reinhardt, Christopher J; Sedgwick, Adam C; Su, Shengzhang; Lee, Michael C; Chan, Jefferson
J. Am. Chem. Soc. 2021, 143, 7196-7202.

Altered drug metabolism and increased susceptibility to fatty liver disease in an inducible liver-specific mouse model of myotonic dystrophy
Dewald, Zac; Chembazkhi, Ullas V.; Gupta, Andrew; Kalsotra, Auinash
bioRxiv. 2021, DOI:

Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria
Muñoz, Kristen A; Hergenrother, Paul J
Acc. Chem. Res. 2021, 54, 1322-1333.

Advances in Activity-Based Sensing Probes for Isoform-Selective Imaging of Enzymatic Activity
Gardner, Sarah H; Reinhardt, Christopher J; Chan, Jefferson
Angew Chem Int Ed Engl. 2021, 60, 5000-5009.

A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands
Shrestha, Bijay; Rose, Brennan T; Olen, Casey L; Roth, Aaron; Kwong, Adon C; Wang, Yang; Denmark, Scott E
J. Org. Chem. 2021, 86, 3490-3534.

Synthesis of Fusidic Acid Derivatives Yields a Potent Antibiotic with an Improved Resistance Profile
Garcia Chavez, Martin; Garcia, Alfredo; Lee, Hyang Yeon; Lau, Gee W; Parker, Erica N; Komnick, Kailey E; Hergenrother, Paul J
ACS Infect. Dis. 2021, 7, 493-505.

New developments in RiPP discovery, enzymology and engineering
Montalbán-López, Manuel; Scott, Thomas A; Ramesh, Sangeetha; Rahman, Imran R; van Heel, Auke J; Viel, Jakob H; Bandarian, Vahe; Dittmann, Elke; Genilloud, Olga; Goto, Yuki; Grande Burgos, María José; Hill, Colin; Kim, Seokhee; Koehnke, Jesko; Latham, John A; Link, A James; Martínez, Beatriz; Nair, Satish K; Nicolet, Yvain; Rebuffat, Sylvie; Sahl, Hans-Georg; Sareen, Dipti; Schmidt, Eric W; Schmitt, Lutz; Severinov, Konstantin; Süssmuth, Roderich D; Truman, Andrew W; Wang, Huan; Weng, Jing-Ke; van Wezel, Gilles P; Zhang, Qi; Zhong, Jin; Piel, Jörn; Mitchell, Douglas A; Kuipers, Oscar P; van der Donk, Wilfred A
Nat. Prod. Rep. 2021, 38, 130-239.


Compound Uptake into E. coli Can Be Facilitated by N-Alkyl Guanidiniums and Pyridiniums
Perlmutter, Sarah J; Geddes, Emily J; Drown, Bryon S; Motika, Stephen E; Lee, Myung Ryul; Hergenrother, Paul J
ACS Infect. Dis. 2020, 7, 162-173.

Species and sex differences in eye morphometry and visual responsivity of two crepuscular sweat bee species
Jones, Beryl M; Seymoure, Brett M; Comi, Troy J; Loew, Ellis R
Biological Journal of the Linnean Society. 2020, 130, 533-544.

Interaction of Alpha-Synuclein and its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature
McClain, S. M.; Ojoawo, A.; Lin, W.; Rienstra, C. M.; Murphy, C. J.
ACS Nano. 2020, 14, 10153-10167.

Abstract P5-05-05: Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds
Ziegler, Yvonne; Laws, Mary J; Guillen, Valeria S.; Kim, SungHoon; Dey, Parama; Smith, Brandi P; Gong, Ping; Bindman, Noah; Zhao, Yuechao; Carlson, Kathryn; Yasuda, Mayuri A; Singh, Divya; Li, Zhong; El-Ashry, Dorraya; Madak-Erdogan, Zeynep; Katzenellenbogen, Benita S; Katzenellenbogen, John A
Cancer Res. 2020, DOI:

Abstract P6-04-10: Combining direct and indirect modes of antiestrogen ligand antagonism of estrogen receptor activity in breast cancer
Min, Jian; Srinivasan, Sathish; Rangaranjan, Erumbi S; Nwachukwu, Jerome C; Guillen, Valeria S; Ziegler, Yvonne; Yan, Shunchao; Carlson, Kathryn E; Hou, Yingwei; Kim, SungHoon; Izard, Tina; Houtman, Rene; Nettles, Kendall W; Katzenellenbogen, Benita S; Katzenellenbogen, John A
Cancer Res. 2020, DOI:

Re-engineering natural products to engage new biological targets
Motika, Stephen E; Hergenrother, Paul J
Nat. Prod. Rep. 2020, 37, 1395-1403.

Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors
Hagler, Lauren D; Luu, Long M; Tonelli, Marco; Lee, JuYeon; Hayes, Samuel M; Bonson, Sarah E; Vergara, J Ignacio; Butcher, Samuel E; Zimmerman, Steven C
Biochemistry. 2020, 59, 3463-3472.

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment
Li, Yin; Coons, Laurel A; Houtman, René; Carlson, Kathryn E; Martin, Teresa A; Mayne, Christopher G; Melchers, Diana; Jefferson, Tanner B; Ramsey, J Tyler; Katzenellenbogen, John A; Korach, Kenneth S
Sci Signal. 2020, 13

Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage
Yu, Zuo Hang; Reinhardt, Christopher J; Wong, Thomas Hin-Fung; Tong, Ka Yan; Chan, Jefferson; Au-Yeung, Ho Yu
Chemistry. 2020, 26, 8794-8800.

Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA
Chien, Ching-Ming; Wu, Pei-Ching; Satange, Roshan; Chang, Cheng-Chung; Lai, Zi-Lun; Hagler, Lauren D; Zimmerman, Steven C; Hou, Ming-Hon
J. Am. Chem. Soc. 2020, 142, 11165-11172.

Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast
Hou, Jennifer; Daniels, Page N; Burke, Martin D
ACS Chem Biol. 2020, 15, 1575–1580.

Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2
Rahman, Imran R; Acedo, Jeella Z; Liu, Xiaoran Roger; Zhu, Lingyang; Arrington, Justine; Gross, Michael L; van der Donk, Wilfred A
ACS Chem Biol. 2020, 15, 1473-1486.

Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch
Motika, Stephen E; Ulrich, Rebecca J; Geddes, Emily J; Lee, Hyang Yeon; Lau, Gee W; Hergenrother, Paul J
J. Am. Chem. Soc. 2020, 142, 10856-10862.

An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells
Yadav, Anuj K; Reinhardt, Christopher J; Arango, Andres S; Huff, Hannah C; Dong, Liang; Malkowski, Michael G; Das, Aditi; Tajkhorshid, Emad; Chan, Jefferson
Angew Chem Int Ed Engl. 2020, 59, 3307-3314.

Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations
Svec, Riley L; Hergenrother, Paul J
Angew Chem Int Ed Engl. 2020, 59, 1857-1862.

A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold To Arrest Cell Migration
Smaga, Lukas P; Pino, Nicholas W; Ibarra, Gabriela E; Krishnamurthy, Vishnu; Chan, Jefferson
J. Am. Chem. Soc. 2020, 142, 680-684.

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens
Parker, Erica N; Drown, Bryon S; Geddes, Emily J; Lee, Hyang Yeon; Ismail, Nahed; Lau, Gee W; Hergenrother, Paul J
Nat. Microbiol. 2020, 5, 67-75.

Near-infrared photoactivatable nitric oxide donors with photoacoustic readout
Zhou, Effie Y; Knox, Hailey J; Reinhardt, Christopher J; Partipilo, Gina; Chan, Jefferson
Methods Enzymol. 2020, 641, 113-147

Measurement of Absolute Concentration at the Subcellular Scale
Gorman, Brittney L; Brunet, Melanie A; Pham, Susan N; Kraft, Mary L
ACS Nano. 2020, 14, 6414-6419

Nitric oxide imaging in cancer enabled by steric relaxation of a photoacoustic probe platform 
Reinhardt, Christopher J; Xu, Ruiwen; Chan, Jefferson
Chem. Sci. 2020, 11, 1587-1592.


An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells
Yadav, Anuj K; Reinhardt, Christopher J; Arango, Andres S.; Huff, Hannah C; Dong, Liang, Malkowski, Michael G; Das, Aditi; Tajkhorshid, Emad; Chan, Jefferson
Angewandte Chemie. 2019, 132, 3333-3340.

Influence of Nucleoid-Associated Proteins on DNA Supercoiling
Dahlke, Katelyn; Sing, Charles E
J. Phys. Chem. B. 2019, 123, 10152-10162.

Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking
Montemayor, Eric J; Virta, Johanna M; Hagler, Lauren D; Zimmerman, Steven C; Butcher, Samuel E
Acta Crystallogr F Struct Biol Commun. 2019, 75, 652-656.

Bacteriophage Targeting of Gut Bacterium Attenuates Alcoholic Liver Disease
Duan, Y.; Llorente, C.; Brand, K.; Chu, H.; Jiang, L.; Lang, S.; Torralba, M.; Shao, Y.; Liu, J.; Hernandez-Morales, A.; Lessor, L.; Rahman, I.R.; Miyamoto, Y.; Ly, M.; Sun, W.; Kiesel, R.; Hutmacher, F.; Lee, S.; Ventura-Cots, M.; Bosques-Padilla, F.; Verna, E.C.; Abraldes, J.G.; Brown Jr, R.S.; Vargas, V.; Altamirano, J.; Caballería, J.; Shawcross, D.; Ho, S.B.; Louvet, A.; Lucey, M.R.; Mathurin, P.; Garcia-Tsao, G.; Bataller, R.; Tu, X.M.; Eckmann, L.; van der Donk, W.A.; Young, R.; Trevor, L.; Pride, D.; Stärkel, P.; Fouts, D.E.; Schnabl, B
Nature. 2019, 575, 505-511.

Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098
Nguyen, Kim; DeSieno, Matthew A; Bae, Brian; Johannes, Tyler W; Cobb, Ryan E; Zhao Huimin; Nair, Satish K
Org. Biomol. Chem., 2019, 17, 1506-1518.

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
Richter, Michelle F, Hergenrother, Paul J
Ann NY Acad Sci. 2019, 1435, 18-38.

Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential
Boudreau, Matthew W; Peh, Jessie, Hergenrother, Paul J
ACS Chem. Biol. 2019, 14, 2335–2348.

A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties
Zhou, Effie Y; Knox, Hailey J; Lui, Chang; Zhao, Weili; Chan, Jefferson
J. Am. Chem. Soc. 2019, 141, 17601–17609.

Enantioselective, Lewis Base-Catalyzed, Intermolecular Sulfenoamination of Alkenes
Roth, Aaron; Denmark, Scott E
J. Am. Chem. Soc. 2019, 141, 13767−13771.

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis
Llabani, Evijola; Hicklin, Robert W; Lee, Hyang Yeon; Motika, Stephen E; Crawford, Lisa A; Weerapana, Eranthie; Hergenrother, Paul J
Nat Chem. 2019, 11, 521-532.

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Janin M.; Ortiz-Barahona V.; Boudreau M.W.; Hergenrother P.J.; Esteller M. and others
Acta Neuropathol. 2019138, 1053-1074.

Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis
Precord, Timothy W; Mahanta, Nilkamal; Mitchell, Doug A
ACS Chem. Biol. 2019, 14, 1981–1989

Cell-type specific polysome profiling from mammalian tissues
Seimetz, Joseph; Arif, Wagar; Bangru, Sushant; Hernaez, Mikel; Kalsotra, Auinash
ScienceDirect. 2019, 155, 131-139

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models
Hong, Huiling; Koon, Alex Chun; Chen, Zhefan Stephen; Wei, Yuming; An, Ying; Li, Wen; Lau, Matthew Ho Yan; Lau, Kwok-Fai; Ngo, Jacky Chi Ki; Wong, Chun-Ho; Au-Yeung, Ho Yu; Zimmerman, Steven C; Chan, Ho Yin Edwin
J Biol Chem. 2019, 294, 2757-2770.

Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers
Schlein, Lisa J; Fadl-Alla, Bahaa; Pondenis, Holly C; Lezmi, Stéphane; Eberhart, Charles G; LeBlanc, Amy K; Dickinson, Peter J; Hergenrother, Paul J; Fan, Timothy M
Front. Oncol. 20199, 96

Enantioselective synthesis of isocarbostyril alkaloids and analogs using catalytic dearomative functionalization of benzene
Bingham, T. W.; Hernandez, L. W.; Olson, D. G.; Svec, R. L.; Hergenrother, P. J.; Sarlah, D
J. Am. Chem. Soc. 2019141, 657-670.

Force-Dependent Facilitated Dissociation Can Generate Protein-DNA Catch Bonds
Dahlke, K.; Zhao, Jing; Sing, C. E.; Banigan, Edward J.
ScienceDirect2019117, 1085-1100.


Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate
Drown, Bryon S; Shirai, Tomohiro; Rack, Johannes Gregor Matthias; Ahel, Ivan; Hergenrother, Paul J
Cell Chem Biol. 2018, 25, 1562-1570.

Exploring the Fundamental Structures of Life: Non-targeted, Chemical Analysis of Single Cells and Subcellular Structures
Neumann, E.K.; Do, T.D. ; Comi, T.J.; Sweedler, J.V.
Angew. Chemie Int. Ed. Engl. 2019, 58, 9348–9364.

Preparation of Structurally Diverse Compounds from the Natural Product Lycorine
Tasker, Sarah Z; Cowfer, Amanda E; Hergenrother, Paul J
Org. Lett. 2018, 20, 5894–5898.

Near-Infrared Photoactivatable Nitric Oxide Donors with Integrated Photoacoustic Monitoring
Zhou, Effie Y; Knox, Hailey J; Reinhardt, Christopher J; Partipilo, Gina; Nilges, Mark J; Chan, Jefferson
J. Am. Chem. Soc. 2018, 140, 11686–11697.

Going on offense against the Gram-negative defense
Drown, Bryon S; Hergenrother, Paul J
Proc Natl. Acad. Sci. 2018, 115, 6530-6532.

Targeting Multidrug-resistant Ovarian Cancer Through Estrogen Receptor α Dependent ATP Depletion Caused by Hyperactivation of the Unfolded Protein Response
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Oncotarget 2016, 9, 14741-14753.

Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma
Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. F.; Riggins, G. J.; Hergenrother, P. J.
ACS Chem Biol., 2018, 13, 11, 3206-3216

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain
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Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1
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Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
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Nat Struct Mol Biol, 2018, 25, 928-939

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin
Hegemann, J. D.; Schwalen, C. J.; Mitchell, D. A.; van der Donk, W. A.
Chem Comm2018, 54, 65, 9007-9010

Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
Peh, J.; Boudreau, M. W.; Smith, H. M.; Hergenrother, P.J.
Cell Chemical Biology, 2018, 25, 8, 927-928

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics
Schwalen, C. J.; Hudson, G. A.; Kille, B.; Mitchell, D. A.
J. Am. Chem. Soc., 2018, 140, 30, 9494-9501

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons
Wang, L.; Guillen, V. S.; Sharma, N.; Min, J.; Carlson, K. E.; Toy, W.; Bragi, S.; Katzenellenbogen, B. S.; Chandarlapaty, S.; Sharma, A.
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A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes
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Chem. Sci., 2018, 9, 4937-4941

Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal
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Langmuir, 2018, 34, 50, 15276-15282

Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers
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Development of Photoacoustic Probes for in Vivo Molecular Imaging
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Biochemistry, 2018,  57, 194−199.

Cytosolic delivery of multi-domain cargos by the N-terminus of Pasteurella multocida toxin 
Clemons, N.C.; Bannai, Y.; Haywood, E.E.; Xu, Y.; Buschbach, J.D.; Ho, M.; Wilson, B.A.
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Modular domain swapping among the bacterial cytotoxic necrotizing factor (CNF) family for efficient cargo delivery into mammalian cells
Haywood, E.E.; Ho, H.; Wilson, B.A.
J Biol Chem, 2018293(10), 3860-3870.

Force-extension behavior of DNA in the presence of DNA-bending nucleoid associated proteins
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Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
Harris, D. T.; Hager, M. V.; Smith, S. N.; Cai, Q.; Stone, J. D.; Kruger, P.; Lever, M.; Dushek, O.; Schmitt, T. M.; Greenberg, P. D.; Kranz, D. M.
J Immunol, 2018200(3), 1088-1100

Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins
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Chemphyschem, 201819(10), 1180-1191

A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide
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J Am Chem Soc, 2018, 140(3), 1011-1018


Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity
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Hum. Mol. Genet. 201726 (20), 3895-3908

Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain
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NitroxylFlour: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl
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Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism
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Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
Joshi, A.D.; Botham, R.C.; Schlein, L.J.; Roth, H.S.; Mangraviti, A.; Borodovsky, A.; Tyler, B.; Joselyn, S.; Podell, M.; Fan, T.M., Hergenrother, P.J.;Riggins, G.J.
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Structure-Activity Relationships of the S-Linked Glycocin Sublancin
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Poly(A) tail length regulates PABPC1 expression to tune translation in the heart
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A new genome-mining tool redefines the lasso peptide biosynthetic landscape
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The GlcN6P cofactor serves multiple catalytic roles in the glmS ribozyme
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Profiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
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Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products
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ACS Cent. Sci. 20173, 629-638.

MALDI MS Guided Liquid Microjunction Extraction for Capillary Electrophoresis-Electrospray Ionization MS Analysis of Single Pancreatic Islet Cells
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Anal. Chem. 201789, 7765-7772.

microMS: A Python Platform for Image-Guided Mass Spectrometry Profiling
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Deletion of the K1L Gene Results in a Vaccinia Virus That Is Less Pathogenic Due to Muted Innate Immune Responses, yet Still Elicits Protective Immunity
Bravo Cruz, A.G.; Han, A.; Roy, E.J.; Guzmán, A.B.; Miller, R.J.; Driskell, E.A.; O’Brien, W.D. Jr;. Shisler, J.L.
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Predictive compound accumulation rules yield a broad-spectrum antibiotic
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Head-to-Head Prenyl Synthases in Pathogenic Bacteria
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Chembiochem 201718, 985-991.

Deleting the DAG kinase Dgk1 augments yeast vacuole fusion through increased Ypt7 activity and altered membrane fluidity
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YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function
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Cyclic tensile strain enhances human mesenchymal stem cell Smad 2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds
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Eur. Cell Mater. 201733, 227-239.

Single Cell Profiling Using Ionic Liquid Matrix-Enhanced Secondary Ion Mass Spectrometry for Neuronal Cell Type Differentiation
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Categorizing Cells on the Basis of their Chemical Profiles: Progress in Single-Cell Mass Spectrometry
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Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis
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Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads
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ACS Chem. Biol. 201712, 456-463.​

DNA-Catalyzed DNA Cleavage by a Radical Pathway with Well-Defined Products
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The influence of pore size and stiffness on tenocyte bioactivity and transcriptomic stability in collagen-GAG scaffolds
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A one-step matrix application method for MALDI mass spectrometry imaging of bacterial colony biofilms
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Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins
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Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin
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J. Am. Chem. Soc. 2016138, 15511-15514.​

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics
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Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer
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Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells
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Single Cell Peptide Heterogeneity of Rat Islets of Langerhans
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The Central Polybasic Region of the Soluble SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Vam7 Affects Binding to Phosphatidylinositol 3-Phosphate by the PX (Phox Homology) Domain
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Phosphatidic Acid Sequesters Sec18p from cis-SNARE Complexes to Inhibit Priming
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DNA-catalyzed glycosylation using aryl glycoside donors
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Anticipatory UPR Activation: A Protective Pathway and Target in Cancer
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CRISPR/Cas9 mediated targeted mutagenesis of the fast growing cyanobacterium Synechococcus elongatus UTEX 2973
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In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products
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On-Tissue Derivatization via Electrospray Deposition for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Endogenous Fatty Acids in Rat Brain Tissues
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Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action
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Metal-assisted polyatomic SIMS and laser desorption/ionization for enhanced small molecule imaging of bacterial biofilms
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Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis
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DNA-Catalyzed Amide Hydrolysis
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Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides
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Photopolymerization of Dienoyl Lipids Creates Planar Supported Poly(lipid) Membranes with Retained Fluidity
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New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products
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Synchronized Desorption Electrospray Ionization Mass Spectrometry Imaging
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Accelerated genome engineering through multiplexing
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A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
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Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide
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C3-OH of Amphotericin B Plays an Important Role in Ion Conductance
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Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage
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Biosynthesis of a Novel Glutamate Racemase Containing a Site-Specific 7-Hydroxycoumarin Amino Acid: Enzyme-Ligand Promiscuity Revealed at the Atomistic Level
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CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche
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Identifying States along the Hematopoietic Stem Cell Differentiation Hierarchy with Single Cell Specificity via Raman Spectroscopy
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The phosphoenolpyruvate:sugar phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin
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Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging
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Genetic, Genomic, and Transcriptomic Studies of Pyruvate Metabolism in Methanosarcina barkeri Fusaro
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Binuclear Cu(A) Formation in Biosynthetic Models of Cu(A) in Azurin Proceeds via a Novel Cu(Cys)2His Mononuclear Copper Intermediate
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Recent advances in biosynthetic modeling of nitric oxide reductases and insights gained from nuclear resonance vibrational and other spectroscopic studies
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Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells
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Electrochemical nanoprobes for the chemical detection of neurotransmitters
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A Reaction-Based Fluorescent Probe for Imaging of Formaldehyde in Living Cells
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Multistage Reactive Transmission-Mode Desorption Electrospray Ionization Mass Spectrometry
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A prevalent peptide-binding domain guides ribosomal natural product biosynthesis
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Antibiotic efficacy is linked to bacterial cellular respiration
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Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family
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Classification of Large Cellular Populations and Discovery of Rare Cells Using Single Cell Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
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Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products
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HIV protease inhibitors block streptolysin S production
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Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics
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Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
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Nat. Commun. 20156, 6947.

Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering
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Hemagglutinin clusters in the plasma membrane are not enriched with cholesterol and sphingolipids
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Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase
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A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase
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Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution
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Mineralized collagen scaffolds induce hMSC osteogenesis and matrix remodeling
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The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese
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Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete
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Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor
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Secondary ion mass spectrometry and Raman spectroscopy for tissue engineering applications
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Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB
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Collagen scaffold arrays for combinatorial screening of biophysical and biochemical regulators of cell behavior
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Nanopipet-Based Liquid-Liquid Interface Probes for the Electrochemical Detection of Acetylcholine, Tryptamine, and Serotonin via Ionic Transfer
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T Cell Receptor Engineering and Analysis Using the Yeast Display Platform
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Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17
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Changing the peptide specificity of a human T-cell receptor by directed evolution
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Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB
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Backbone and side-chain assignments of an effector membrane localization domain from Vibrio vulnificus MARTX toxin
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Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis
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Collagen-GAG scaffold biophysical properties bias MSC lineage choice in the presence of mixed soluble signals
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A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains
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Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
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DNA-catalyzed lysine side chain modification
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Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO
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Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation
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π-π interaction energies as determinants of the photodimerization of mono-, di-, and triazastilbenes
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Identifying the lineages of individual cells in cocultures by multivariate analysis of Raman spectra
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Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling
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Cross-linkable liposomes stabilize a magnetic resonance contrast-enhancing polymeric fastener
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Backbone and side-chain resonance assignments of the membrane localization domain from Pasteurella multocida toxin
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Award Winner in the Young Investigator Category, 2014 Society for Biomaterials Annual Meeting and Exposition, Denver, Colorado, April 16-19, 2014: Periodically perforated core-shell collagen biomaterials balance cell infiltration, bioactivity, and mechanical properties
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NMR structure of the S-linked glycopeptide sublancin 168
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Spectroscopic and computational study of a nonheme iron nitrosyl center in a biosynthetic model of nitric oxide reductase
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Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity
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Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity
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The extracellular protein VlsE is destabilized inside cells
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The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation
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Mode of action and structure-activity relationship studies of geobacillin I
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The impact of discrete compartments of a multi-compartment collagen-GAG scaffold on overall construct biophysical properties
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A polymeric fastener can easily functionalize liposome surfaces with gadolinium for enhanced magnetic resonance imaging
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Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit
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Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes
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DNA-catalyzed hydrolysis of esters and aromatic amides
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A liposome-based ion release impedance sensor for biological detection
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Biomed. Microdevices 2013, 15, 895-905. 

Directed Evolution: Past, Present and Future
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Sphingolipid domains in the plasma membranes of fibroblasts are not enriched with cholesterol
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Composite growth factor supplementation strategies to enhance tenocyte bioactivity in aligned collagen-GAG scaffolds
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Directed evolution as a powerful synthetic biology tool
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A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products
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Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts
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Lanthanide ions as required cofactors for DNA catalysts
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Evolution of lanthipeptide synthetases
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Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis
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The influence of collagen-glycosaminoglycan scaffold relative density and microstructural anisotropy on tenocyte bioactivity and transcriptomic stability
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J. Mech. Behav. Biomed. Mater. 201211, 27-40. 

Identifying differentiation stage of individual primary hematopoietic cells from mouse bone marrow by multivariate analysis of TOF-secondary ion mass spectrometry data
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Differential effects of procaspase-3 activating compounds in the induction of cancer cell death
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Fluorinated colloidal gold immunolabels for imaging select proteins in parallel with lipids using high-resolution secondary ion mass spectrometry
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Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase
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Covalent tagging of phosphorylated peptides by phosphate-specific deoxyribozymes
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Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG)
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The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-κB activation by interacting with the IκB kinase complex
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Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)
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DNA-catalyzed reactivity of a phosphoramidate functional group and formation of an unusual pyrophosphoramidate linkage
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VITAL NMR: using chemical shift derived secondary structure information for a limited set of amino acids to assess homology model accuracy
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Discovery and biosynthesis of phosphonate and phosphinate natural products
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Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics
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The development of collagen-GAG scaffold-membrane composites for tendon tissue engineering
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New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF
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Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs
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Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ
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A complex lipoate utilization pathway in Listeria monocytogenes
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Quantitative photochemical immobilization of biomolecules on planar and corrugated substrates: a versatile strategy for creating functional biointerfaces
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Nine post-translational modifications during the biosynthesis of cinnamycin
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Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase
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Biochemistry 201150, 6598-6605. 

The effect of anisotropic collagen-GAG scaffolds and growth factor supplementation on tendon cell recruitment, alignment, and metabolic activity
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Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate
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Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin
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Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin
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The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica
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Probing dynamic cell-substrate interactions using photochemically generated surface-immobilized gradients: application to selectin-mediated leukocyte rolling
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The generation of biomolecular patterns in highly porous collagen-GAG scaffolds using direct photolithography
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Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes
Bertini, S.; De Cupertinis, A.; Granchi, C.; Bargagli, B.; Tuccinardi, T.; Martinelli, A.; Macchia, M.; Gunther, J.R.; Carlson, K.E.; Katzenellenbogen, J.A.; Minutolo, F.
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Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities
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A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis
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A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis
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The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation
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On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase
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Bacillus anthracis spore interactions with mammalian cells: relationship between germination state and the outcome of in vitro
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Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases
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Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate
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Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis
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Direct, Electrocatalytic Oxygen Reduction by Laccase on Anthracene-2-methanethiol Modified Gold
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Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound
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General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates
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Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster
Circello, B.T.; Eliot, A.C.; Lee, J.H.; van der Donk, W.A.; Metcalf, W.W.
Chem. Biol. 201017, 402-411.

Exit strategies for charged tRNA from GluRS
Black Pyrkosz, A.; Eargle, J.; Sethi, A.; Luthey-Schulten, Z.
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DNA-catalyzed serine side chain reactivity and selectivity
Sachdeva, A.; Silverman, S.K.
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Monitoring a coordinated exchange process in a four-component biological interaction system: development of a time-resolved terbium-based one-donor/three-acceptor multicolor FRET system
Kim, S.H.; Gunther, J.R.; Katzenellenbogen, J.A.
J. Am. Chem. Soc. 2010132, 4685-4692.

Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis
Peterson, Q.P.; Goode, D.R.; West, D.C.; Botham, R.C.; Hergenrother, P.J.
Nat. Protoc. 20105, 294-302.

Deciphering the late biosynthetic steps of antimalarial compound FR-900098
Johannes, T.W.; DeSieno, M.A.; Griffin, B.M.; Thomas, P.M.; Kelleher, N.L.; Metcalf, W.W.; Zhao, H.
Chem. Biol. 201017, 57-64.


Synthesis of biphenyl proteomimetics as estrogen receptor-α coactivator binding inhibitors
Williams, A.B.; Weiser, P.T.; Hanson, R.N.; Gunther, J.R.; Katzenellenbogen, J.A.
Org. Lett. 200911, 5370-5373.

Rationally tuning the reduction potential of a single cupredoxin beyond the natural range
Marshall, N.M.; Garner, D.K.; Wilson, T.D.; Gao, Y.G.; Robinson, H.; Nilges, M.J.; Lu, Y.
Nature 2009462, 113-116. 

DNA-catalyzed sequence-specific hydrolysis of DNA
Chandra, M.; Sachdeva, A.; Silverman, S.K.
Nat. Chem. Biol. 20095, 718-720. 

Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3
Peterson, Q.P.; Hsu, D.C.; Goode, D.R.; Novotny, C.J.; Totten, R.K.; Hergenrother, P.J.
J. Med. Chem. 200952, 5721-5731.

Direct biophotolithographic method for generating substrates with multiple overlapping biomolecular patterns and gradients
Toh, C.R.; Fraterman, T.A.; Walker, D.A.; Bailey, R.C.
Langmuir200925, 8894-8898.

The Thermoplasma acidophilum LplA-LplB complex defines a new class of bipartite lipoate-protein ligases
Christensen, Q.H.; Cronan, J.E.
J. Biol. Chem. 2009284, 21317-21326.

Alternative inhibition of androgen receptor signaling: peptidomimetic pyrimidines as direct androgen receptor/coactivator disruptors
Gunther, J.R.; Parent, A.A.; Katzenellenbogen, J.A.
ACS Chem. Biol. 20094, 435-440.

PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition
Peterson, Q.P.; Goode, D.R.; West, D.C.; Ramsey, K.N.; Lee, J.J.; Hergenrother, P.J.
J. Mol. Biol. 2009388, 144-158.

A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding
Gunther, J.R.; Du, Y.; Rhoden, E.; Lewis, I.; Revennaugh, B.; Moore, T.W.; Kim, S.H.; Dingledine, R.; Fu, H.; Katzenellenbogen, J.A.
J. Biomol. Screen. 200914, 181-193.


Inhibition of Bacillus anthracis spore outgrowth by nisin
Gut, I.M.; Prouty, A.M.; Ballard, J.D.; van der Donk, W.A.; Blanke, S.R.
Antimicrob. Agents Chemother. 200852, 4281-4288.

Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor
LaFrate, A.L.; Gunther, J.R.; Carlson, K.E.; Katzenellenbogen, J.A.
Bioorg. Med. Chem. 200816, 10075-10084.

Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner
Kim, S.H,; Gunther, J.R.; Katzenellenbogen, J.A.
Org. Lett. 200810, 4931-4934.

Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding
Parent, A.A.; Gunther, J.R.; Katzenellenbogen, J.A.
J. Med. Chem. 200851, 6512-6530.

Structure-activity relationship studies of the two-component lantibiotic haloduracin
Cooper, L.E.; McClerren, A.L.; Chary, A.; van der Donk, W.A.
Chem. Biol. 200815, 1035-1045.

Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase
Rakus, J.F.; Fedorov, A.A.; Fedorov, E.V.; Glasner, M.E.; Hubbard, B.K.; Delli, J.D.; Babbitt, P.C.; Almo, S.C.; Gerlt, J.A.
Biochemistry 200847, 9944-9954.

Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line
Magarvey, N.A.; Fortin, P.D.; Thomas, P.M.; Kelleher, N.L.; Walsh, C.T.
ACS Chem. Biol. 20083, 542-554.

Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098
Eliot, A.C.; Griffin, B.M.; Thomas, P.M.; Johannes, T.W.; Kelleher, N.L.; Zhao, H.; Metcalf, W.W.
Chem. Biol. 200815, 765-770.

Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways
Shao, Z.; Blodgett, J.A.; Circello, B.T.; Eliot, A.C.; Woodyer, R.; Li, G.; van der Donk, W.A.; Metcalf, W.W.; Zhao, H.
J. Biol. Chem2008283, 23161-23168.

The importance of the leader sequence for directing lanthionine formation in lacticin 481
Patton, G.C.; Paul, M.; Cooper, L.E.; Chatterjee, C.; van der Donk, W.A.
Biochemistry 200847, 7342-7351. 

Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction
Gunther, J.R.; Moore, T.W.; Collins, M.L.; Katzenellenbogen, J.A.
ACS Chem. Biol. 20083, 282-286.

Dynamics of Recognition between tRNA and elongation factor Tu
Eargle, J.; Black, A.A.; Sethi, A.; Trabuco, L.G.; Luthey-Schulten, Z.
J. Mol. Biol. 2008377, 1382-1405.

Deconstruction of iterative multidomain polyketide synthase function
Crawford, J.M.; Thomas, P.M.; Scheerer, J.R.; Vagstad, A.L.; Kelleher, N.L.; Townsend, C.A.
Science 2008320, 243-246.


Evolution of enzymatic activities in the enolase superfamily: D-Mannonate dehydratase from Novosphingobium aromaticivorans
Rakus, J.F.; Fedorov, A.A.; Fedorov, E.V.; Glasner, M.E.; Vick, J.E.; Babbitt, P.C.; Almo, S.C.; Gerlt, J.A.
Biochemistry 200746, 12896-12908.

Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers
Parks, B.A.; Jiang, L.; Thomas, P.M.; Wenger, C.D.; Roth, M.J.; Boyne, M.T. 2nd; Burke, P.V.; Kwast, K.E.; Kelleher, N.L.
Anal. Chem. 200779, 7984-7991.

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide
Blodgett, J.A.; Thomas, P.M.; Li, G.; Velasquez, J.E.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W.
Nat. Chem. Biol. 20073, 480-485.

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid
Whitteck, J.T.; Ni, W.; Griffin, B.M.; Eliot, A.C.; Thomas, P.M.; Kelleher, N.L.; Metcalf, W.W.; van der Donk, W.A.
Angew. Chem. Int. Ed. 200746, 9089-9092.


Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster
Woodyer, R.D.; Shao, Z.; Thomas, P.M.; Kelleher, N.L.; Blodgett, J.A.; Metcalf, W.W.; van der Donk, W.A.; Zhao, H.
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