PUBLICATIONS
Research has been published in over 220 articles by our trainees and their mentors partially in thanks to funding from T32 GM070421.
2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006
2020
RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery
Kloosterman, Alexander M.; Shelton, Kyle E.; van Wezel, Gilles P.; Medema, Marnix H.; Mitchell, Douglas A.
mSystems. 2020, Sept 01; 5 (5) e00267-20; DOI: 10.1128/mSystems.00267-20
Interaction of Alpha-Synuclein and Its Mutants with Rigid Lipid Vesicle Mimics of Varying Surface Curvature
McClain, Sophia M.; Ojoawo, Adedolapo M.; Lin, Wayne; Rienstra, Chad M.; Murphy, Catherine J.
ACS Nano. 2020 July 16; 14(8):10153-10167.
Imidazotetrazines as Weighable Diazomethane Surrogates for Esterifications and Cyclopropanations.
Svec, Riley L; Hergenrother, Paul J
Angewandte Chemie (International ed. in English). 2020 Jan 27; 59 (5):1857-1862
2019
Bingham, Tanner W; Hernandez, Lucas W; Olson, Daniel G; Svec, Riley L; Hergenrother, Paul J; Sarlah, David
Journal of the American Chemical Society. 2019 Jan 09; 141 (1): 657-670
Janin, Maxime; Ortiz-Barahona, Vanessa; de Moura, Manuel Castro; Martínez-Cardús, Anna; Llinàs-Arias, Pere; Soler, Marta; Nachmani, Daphna; Pelletier, Joffrey; Schumann, Ulrike; Calleja-Cervantes, Maria E; Moran, Sebastian; Guil, Sonia; Bueno-Costa, Alberto; Piñeyro, David; Perez-Salvia, Montserrat; Rosselló-Tortella, Margalida; Piqué, Laia; Bech-Serra, Joan J; De La Torre, Carolina; Vidal, August; Martínez-Iniesta, María; Martín-Tejera, Juan F; Villanueva, Alberto; Arias, Alexandra; Cuartas, Isabel; Aransay, Ana M; La Madrid, Andres Morales; Carcaboso, Angel M; Santa-Maria, Vicente; Mora, Jaume; Fernandez, Agustin F; Fraga, Mario F; Aldecoa, Iban; Pedrosa, Leire; Graus, Francesc; Vidal, Noemi; Martínez-Soler, Fina; Tortosa, Avelina; Carrato, Cristina; Balañá, Carme; Boudreau, Matthew W; Hergenrother, Paul J; Kötter, Peter; Entian, Karl-Dieter; Hench, Jürgen; Frank, Stephan; Mansouri, Sheila; Zadeh, Gelareh; Dans, Pablo D; Orozco, Modesto; Thomas, George; Blanco, Sandra; Seoane, Joan; Preiss, Thomas; Pandolfi, Pier Paolo; Esteller, Manel
Acta neuropathologica. 2019 12; 138 (6): 1053-1074
Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential
Boudreau, Matthew W; Peh, Jessie; Hergenrother, Paul J
ACS Chem Biol. 2019 Nov 15; 14(11): 2335–2348.
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
Duan, Yi; Llorente, Cristina; Lang, Sonja; Brandl, Katharina; Chu, Huikuan; Jiang, Lu; White, Richard C; Clarke, Thomas H; Nguyen, Kevin; Torralba, Manolito; Shao, Yan; Liu, Jinyuan; Hernandez-Morales, Adriana; Lessor, Lauren; Rahman, Imran R; Miyamoto, Yukiko; Ly, Melissa; Gao, Bei; Sun, Weizhong; Kiesel, Roman; Hutmacher, Felix; Lee, Suhan; Ventura-Cots, Meritxell; Bosques-Padilla, Francisco; Verna, Elizabeth C; Abraldes, Juan G; Brown Jr, Robert S; Vargas, Victor; Altamirano, Jose; Caballería, Juan; Shawcross, Debbie L; Ho, Samuel B; Louvet, Alexandre; Lucey, Michael R; Mathurin, Philippe; Garcia-Tsao, Guadalupe; Bataller, Ramon; Tu, Xin M; Eckmann, Lars; van der Donk, Wilfred A; Young, Ry; Lawley, Trevor D; Stärkel, Peter; Pride, David; Fouts, Derrick E; Schnabl, Bernd
Nature. 2019 Nov;575(7783):505-511
A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties
Zhou, Effie Y; Knox, Hailey J; Liu, Chang; Zhao, Weili; Chan, Jefferson
J Am Chem Soc. 2019 Nov 6;141(44):17601-17609
Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis
Precord, Timothy W; Mahanta, Nilkamal; Mitchell, Douglas A
ACS Chem Biol. 2019 Sep 20;14(9):1981-1989.
Force-Dependent Facilitated Dissociation Can Generate Protein-DNA Catch Bonds
Dahlke, Katelyn; Zhao, Jing; Sing, Charles E; Banigan, Edward J
Biophys J. 2019 Sep 17;117(6):1085-1100
Enantioselective, Lewis Base-Catalyzed, Intermolecular Sulfenoamination of Alkenes
Roth, Aaron; Denmark, Scott E
J Am Chem Soc. 2019 Sep 4;141(35):13767-13771
Exploring the Fundamental Structures of Life: Non-Targeted, Chemical Analysis of Single Cells and Subcellular Structures
Neumann, Elizabeth K; Do, Thanh D; Comi, Troy J; Sweedler, Jonathan V
Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9348-9364
Development of novel macrocyclic small molecules that target CTG trinucleotide repeats
Serrano, Julio F; Lee, JuYeon; Daniel Curet, L; Hagler, Lauren D; Bonson, Sarah E; Schuster, Emma J; Zimmerman, Steven C
Bioorg Med Chem. 2019 Jul 1;27(13):2978-2984
Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides
Hudson, Graham A; Burkhart, Brandon J; DiCaprio, Adam J; Schwalen, Christopher J; Kille, Bryce; Pogorelov, Taras V; Mitchell, Douglas A
J Am Chem Soc. 2019 May 22;141(20):8228-8238
Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
Lee, JuYeon; Bai, Yugang; Chembazhi, Ullas V; Peng, Shaohong; Yum, Kevin; Luu, Long M; Hagler, Lauren D; Serrano, Julio F; Chan, H Y Edwin; Kalsotra, Auinash; Zimmerman, Steven C
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8709-8714
Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins
Thirawatananond, Puchong; McPherson, Robert Lyle; Malhi, Jasmine; Nathan, Sara; Lambrecht, Michael J; Brichacek, Matthew; Hergenrother, Paul J; Leung, Anthony K L; Gabelli, Sandra B
Sci Rep. 2019; 9: 5940.
Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098
Nguyen, Kim; DeSieno, Matthew A; Bae, Brian; Johannes, Tyler W; Cobb, Ryan E; Zhao, Huimin; Nair, Satish K
Org Biomol Chem. 2019 Feb 6;17(6):1506-1518.
Cell-type specific polysome profiling from mammalian tissues
Seimetz, Joseph; Arif, Waqar; Bangru, Sushant; Hernaez, Mikel; Kalsotra, Auinash
Methods. 2019 Feb 15;155:131-139.
The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
Ritcher, M. F.; Hergenrother, P. J.
Ann N Y Acad Sci. 2019, 1435, 18-38.
2018
Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma
Svec, R. L.; Furiassi, L.; Skibinski, C. G.; Fan, T. F.; Riggins, G. J.; Hergenrother, P. J.
ACS Chem Biol., 2018, 13, 11, 3206-3216
Sharma, Abhishek; Toy, Weiyi; Guillen, Valeria Sanabria; Sharma, Naina; Min, Jian; Carlson, Kathryn E; Mayne, Christopher G; Lin, Shengjia; Sabio, Michael; Greene, Geoffrey; Katzenellenbogen, Benita S; Chandarlapaty, Sarat; Katzenellenbogen, John A
ACS Chem Biol. 2018 Dec 21;13(12):3374-3384
Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1
Anorma, Chelsea; Hedhli, Jamila; Bearrood, Thomas E; Pino, Nicholas W; Gardner, Sarah H; Inaba, Hiroshi; Zhang, Pamela; Li, Yanfen; Feng, Daven; Dibrell, Sara E; Kilian, Kristopher A; Dobrucki, Lawrence W; Fan, Timothy M; Chan, Jefferson
ACS Cent Sci. 2018 Aug 22;4(8):1045-1055
Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
Bangru, S.; Arif, W.; Seimetz, J.; Bhate, A.; Rashan, E. H.; Carstens, R. P.; Anakk, S.; Kalsotra, A.
Nat Struct Mol Biol, 2018, 25, 928-939
Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin
Hegemann, J. D.; Schwalen, C. J.; Mitchell, D. A.; van der Donk, W. A.
Chem Comm, 2018, 54, 65, 9007-9010
Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
Peh, J.; Boudreau, M. W.; Smith, H. M.; Hergenrother, P.J.
Cell Chemical Biology, 2018, 25, 8, 927-928
Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics
Schwalen, C. J.; Hudson, G. A.; Kille, B.; Mitchell, D. A.
J. Am. Chem. Soc., 2018, 140, 30, 9494-9501
New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons
Wang, L.; Guillen, V. S.; Sharma, N.; Min, J.; Carlson, K. E.; Toy, W.; Bragi, S.; Katzenellenbogen, B. S.; Chandarlapaty, S.; Sharma, A.
ACS Med. Chem. Lett., 2018, 9, 8, 803-808
A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes
Welle, T. M.; Alanis, K.; Colombo, M.L.; Sweedler, J. V.; Shen, M.
Chem. Sci., 2018, 9, 4937-4941
Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal
Lee, M. K.; Clay, N. E.; Ko, E.; Smith, C. E.; Chen, L.; Cho, N.; Sung, H.; DiPietro, L.; Lee, J.; Kong, H.
Langmuir, 2018, 34, 50, 15276-15282
Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers
Della Ripa, L. A.; Petros, Z. A.; Cioffi, A. G.; Piehl, D. W.; Courtney, J. M.; Burke, M. D.; Rienstra, C. M.
Methods. 2018, 138-139, 47-53
Development of Photoacoustic Probes for in Vivo Molecular Imaging
Reinhardt, C.J.; Chan, J.
Biochemistry, 2018, 57, 194−199.
Cytosolic delivery of multi-domain cargos by the N-terminus of Pasteurella multocida toxin
Clemons, N.C.; Bannai, Y.; Haywood, E.E.; Xu, Y.; Buschbach, J.D.; Ho, M.; Wilson, B.A.
Infect. Immun. 2018, 86 (8)
Modular domain swapping among the bacterial cytotoxic necrotizing factor (CNF) family for efficient cargo delivery into mammalian cells
Haywood, E.E.; Ho, H.; Wilson, B.A.
J Biol Chem, 2018, 293(10), 3860-3870.
Force-extension behavior of DNA in the presence of DNA-bending nucleoid associated proteins
Dahlke, K.; Sing, C. E.
J Chem Phys, 2018, 148, 84902.
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
Harris, D. T.; Hager, M. V.; Smith, S. N.; Cai, Q.; Stone, J. D.; Kruger, P.; Lever, M.; Dushek, O.; Schmitt, T. M.; Greenberg, P. D.; Kranz, D. M.
J Immunol, 2018, 200(3), 1088-1100
Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins
Do, T. D.; Ellis, J. F.; Neumann, E. K.; Comi, T. J.; Tillmaand, E. G.; Lenhart, A. E.; Rubakhin, S. S.; Sweedler, J. V.
Chemphyschem, 2018, 19(10), 1180-1191
A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide
Reinhardt, C. J.; Zhou, E. Y.; Jorgensen, M. D.; Partipilo, G.; Chan, J.
J Am Chem Soc, 2018, 140(3), 1011-1018
2017
Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity
Liu D.C.; Seimetz J.; Lee K.Y.; Kalsotra A.; Chung H.J.; Lu H.; Tsai N.P.
Hum. Mol. Genet. 2017, 26 (20), 3895-3908
Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain
Skariah G., Seimetz J., Norsworthy M., Lannom M.C., Kenny P.J., Elrakhawy M., Forsthoefel C., Drnevich J.,Kalsotra A., Ceman S.
BMC Biol. 2017, 15:54
NitroxylFlour: A Thiol-Based Fluorescent Probe for Live-Cell Imaging of Nitroxyl
Pino, N.W.; Davis III, J.; Yu, Z.; Chan, J.
J. Am. Chem. Soc., 2017, 139, 18476-18479
Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism
Reed, J.H.; Shi, Y.; Zhu, Q, Chakraborty, S.; Mirts, E.N.; Petrik, I.D.; Bhagi-Damodaran, A.; Ross, M.; Moenne-Loccoz, P.; Zhang, Y.; Lu; Y.
J. Am. Chem. Soc., 2017, 139 (35), 12209–12218.
Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
Joshi, A.D.; Botham, R.C.; Schlein, L.J.; Roth, H.S.; Mangraviti, A.; Borodovsky, A.; Tyler, B.; Joselyn, S.; Podell, M.; Fan, T.M., Hergenrother, P.J.;Riggins, G.J.
Oncotarget. 2017, 8(46), 80124-80138.
Structure-Activity Relationships of the S-Linked Glycocin Sublancin
Biswas, S.; Garcia De Gonzalo, C. V.; Repka, L. M.; van der Donk, W. A.
ACS Chem. Biol., 2017, 12(12), 2965–2969.
Poly(A) tail length regulates PABPC1 expression to tune translation in the heart
Chorghade, S.; Seimetz, J.; Emmons, R.; Yang, J.; Bresson, S. M.; Lisio, M. D.; Parise, G.; Conrad, N. K.; Kalsotra, A.
eLife., 2017, 6, 24139.
A new genome-mining tool redefines the lasso peptide biosynthetic landscape
Tietz, J. I.; Schwalen, C. J.; Patel, Parth S.; Maxson, T.; Blair, P. M.; Tai, H.; Zakai, U. I.; Mitchell, D. A.
Nat Chem Biol. 2017, 13(5), 470-478.
The GlcN6P cofactor serves multiple catalytic roles in the glmS ribozyme
Bingaman, J. L.; Zhang, S.; Stevens, D. R.; Yennawar, N. H.; Hammes-Schiffer, S.;Bevilacqua, P. C.
Nat Chem Biol. 2017, 13(4),439-445.
Si, T.; Li, B.; Comi, T.J.; Wu, Y.; Hu, P.; Wu, Y.; Min, Y.; Mitchell, D.A.; Zhao, H.; Sweedler, J.V.
J. Am. Chem. Soc. 2017, 139, 12466-12473.
Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products
Burkhart, B.J.; Kakkar, N.; Hudson, G.A.; van der Donk, W.A.; Mitchell, D.A.
ACS Cent. Sci. 2017, 3, 629-638.
Comi, T.J.; Makurath, M.A.; Philip, M.C.; Rubakhin, S.S.; Sweedler, J.V.
Anal. Chem. 2017, 89, 7765-7772.
microMS: A Python Platform for Image-Guided Mass Spectrometry Profiling
Comi, T.J.; Neumann, E.K.; Do, T.D.; Sweedler, J.V.
J. Am. Soc. Mass. Spectrom. 2017 [Epub ahead of print].
Bravo Cruz, A.G.; Han, A.; Roy, E.J.; Guzmán, A.B.; Miller, R.J.; Driskell, E.A.; O'Brien, W.D. Jr;. Shisler, J.L.
J. Virol. 2017, 91, pii: e00542-17.
Predictive compound accumulation rules yield a broad-spectrum antibiotic
Richter, M.F.; Drown, B.S.; Riley, A.P.; Garcia, A.; Shirai, T.; Svec, R.L.; Hergenrother, P.J.
Nature 2017, 545, 299-304.
Head-to-Head Prenyl Synthases in Pathogenic Bacteria
Schwalen, C.J.; Feng, X.; Liu, W.; O-Dowd, B.; Ko, T.P.; Shin, C.J.; Guo, R.T.; Mitchell, D.A.; Oldfield, E.
Chembiochem 2017, 18, 985-991.
Miner, G.E.; Starr, M.L.; Hurst, L.R.; Fratti, R.A.
Traffic 2017, 18, 315-329.
YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function
Burkhart, B.J.; Schwalen, C.J.; Mann, G.; Naismith, J.H.; Mitchell, D.A.
Chem. Rev. 2017, 117, 5389-5456
Grier, W.G.; Moy, A.S.; Harley, B.A.
Eur. Cell Mater. 2017, 33, 227-239.
Do T,D.; Comi, T.J.; Dunham, S.J.; Rubakhin, S.S.; Sweedler, J.V.
Anal. Chem. 2017, 89, 3078-3086.
Comi, T.J.; Do, T.D.; Rubakhin, S.S.; Sweedler, J.V.
J. Am. Chem. Soc. 2017, 139, 3920-3929.
Ortega, M.A.; Cogan, D.P.; Mukherjee, S.; Garg, N.; Li, B.; Thibodeaux, G.N.; Maffioli, S.I.; Donadio, S.; Sosio, M.; Escano, J.; Smith, L.; Nair, S.K.; van der Donk, W.A.
ACS Chem. Biol. 2017, 12, 548-557.
Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads
Olivares, P.; Ulrich, E.C.; Chekan, J.R.; van der Donk, W.A.; Nair, S.K.
ACS Chem. Biol. 2017, 12, 456-463.
DNA-Catalyzed DNA Cleavage by a Radical Pathway with Well-Defined Products
Lee, Y.; Klauser, P.C.; Brandsen, B.M.; Zhou, C.; Li, X.; Silverman, S.K.
J. Am. Chem. Soc. 2017, 139, 255-261.
Grier, W.K.; Iyoha, E.M.; Harley, B.A.
J. Mech. Behav. Biomed. Mater. 2017, 65, 295-305.
2016
Li, B.; Comi, T.J.; Si, T.; Dunham, S.J.; Sweedler, J.V.
J. Mass. Spectrom. 2016, 51, 1030-1035.
Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins
Maxson, T.; Tietz, J.I.; Hudson, G.A.; Guo, X.R.; Tai, H.C.; Mitchell, D.A.
J. Am. Chem. Soc. 2016, 138, 15157-15166.
Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin
Zhang, Z.; Hudson, G.A.; Mahanta, N.; Tietz, J.I.; van der Donk, W.A.; Mitchell, D.A.
J. Am. Chem. Soc. 2016, 138, 15511-15514.
Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics
Botham, R.C.; Roth, H.S.; Book, A.P.; Roady, P.J.; Fan, T.M.; Hergenrother, P.J.
ACS Cent. Sci. 2016, 2, 545-559.
Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer
Pollock, J.A.; Wardell, S.E.; Parent, A.A.; Stagg, D.B.; Ellison, S.J.; Alley, H.M.; Chao, C.A.; Lawrence, S.A.; Stice, J.P.; Spasojevic, I.; Baker, J.G.; Kim, S.H.; McDonnell, D.P.; Katzenellenbogen, J.A.; Norris, J.D.
Nat. Chem. Biol. 2016, 12, 795-801.
Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells
Sparks, R.P.; Guida, W.C.; Sowden, M.P.; Jenkins, J.L.; Starr, M.L.; Fratti, R.A.; Sparks, C.E.; Sparks, J.D.
Biochem. Biophys. Res. Commun. 2016, 478, 546-552.
Single Cell Peptide Heterogeneity of Rat Islets of Langerhans
Jansson, E.T.; Comi, T.J.; Rubakhin, S.S.; Sweedler, J.V.
ACS Chem. Biol. 2016, 11, 2588-2595.
Miner, G.E.; Starr, M.L.; Hurst, L.R.; Sparks, R.P.; Padolina M.; Fratti, R.A.
J. Biol. Chem. 2016, 291, 17651-17663.
Phosphatidic Acid Sequesters Sec18p from cis-SNARE Complexes to Inhibit Priming
Starr, M.L.; Hurst, L.R.; Fratti, R.A.
Traffic 2016, 17, 1091-1109.
DNA-catalyzed glycosylation using aryl glycoside donors
Hesser, A.R.; Brandsen, B.M.; Walsh, S.M.; Wang, P.; Silverman, S.K.
Chem. Commun. 2016, 52, 9259-9262.
Anticipatory UPR Activation: A Protective Pathway and Target in Cancer
Shapiro, D.J.; Livezey, M.; Yu, L.; Zheng, X.; Andruska, N.
Trends Endocrinol. Metal. 2016, 27, 731-741.
Wendt, K.E.; Ungerer, J.; Cobb, R.E.; Zhao, H.; Parkrasi, H.B.
Microb. Cell Fact. 2016, 15, 115.
In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products
Deane, C.D.; Burkhart, B.J.; Blair, P.M.; Tietz, J.I.; Lin, A.; Mitchell, D.A.
ACS Chem. Biol. 2016, 11, 2232-2243.
Wu, Q.; Comi, T.J.; Li, B.; Rubakhin, S.S.; Sweedler, J.V.
Anal. Chem. 2016, 88, 5988-5995.
Zheng, X.; Andruska, N.; Yu, L.; Mao, C.; Kim, J.E.; Livezey, M.; Helferich, W.G.; Shapiro, D.J.
Steroids 2016, 114, 2-6.
Dunham, S.J.; Comi, T.J.; Ko, K.; Li, B.; Baig, N.F.; Morales-Soto, N.; Shrout, J.D.; Bohn, P.W.; Sweedler, J.V.
Biointerphases 2016, 11, 02A325.
Ortega, M.A.; Hao, Y.; Walker, M.C.; Donadio, S.; Sosio, M.; Nair, S.K.; van der Donk, W.A.
Cell Chem. Biol. 2016, 23, 370-380.
DNA-Catalyzed Amide Hydrolysis
Zhou, C.; Avins, J.L.; Klauser, P.C.; Brandsen, B.M.; Lee, Y.; Silverman, S.K.
J. Am. Chem. Soc. 2016, 138, 2106-2109.
Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides
Chekan, J.R.; Cogan, D.P.; Nair, S.K.
Med. Chem. Commun. 2016, 7, 28-36.
Orosz, K.S.; Jones, I.W.; Keogh, J.P.; Smith, C.M.; Griffin, K.R.; Xu, J.; Comi, T.J.; Hall, H.K. Jr., Saavedra, S.S.
Langmuir 2016, 32, 1577-1584.
Ortega, M.A.; van der Donk, W.A.
Cell Chem. Biol. 2016, 23, 31-44.
Synchronized Desorption Electrospray Ionization Mass Spectrometry Imaging
Comi, T.J.; Ryu, S.W.; Perry, R.H.
Anal. Chem. 2016, 88, 1169-1175.
Accelerated genome engineering through multiplexing
Bao, Z.; Cobb, R.E.; Zhao, H.
Wiley Interdiscip. Rev. Syst. Biol. Med. 2016, 8, 5-21.
2015
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
Palchaudhuri, R.; Lambrecht, M.J.; Botham, R.C.; Partlow, K.C.; van Ham, T.J.; Putt, K.S.; Nguyen, L.T.; Kim, S.H.; Peterson, R.T.; Fan, T.M.; Hergenrother, P.J.
Cell Rep. 2015, 13, 2027-2036.
Maxson, T.; Bertke, J.A.; Gray, D.L.; Mitchell, D.A.
Acta Crystallogr. E Crystallogr. Commun. 2015, 71, 1401-1407.
C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.
Davis S.A.; Della Ripa, L.A.; Hu, L.; Cioffi, A.G.; Pogorelov, T.V.; Rienstra, C.M.; Burke, M.D.
J. Am. Chem. Soc. 2015, 137, 15102-15104.
Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage
Belenky, P.; Ye, J.D.; Porter, C.B.; Cohen, N.R.; Lobritz, M.A.; Ferrante, T.; Jain, S.; Korry, B.J.; Schwarz, E.G.; Walker, G.C.; Collins, J.J.
Cell Rep. 2015, 13, 968-980.
Dean, S.F.; Whalen, K.L.; Spies, M.A.
ACS Cent. Sci. 2015, 1, 364-373.
Yokohama-Tamaki, T.; Otsu, K.; Harada, H.; Shibata, S.; Obara, N.; Irie, K.; Taniguchi, A.; Nagasawa, T.; Aoki, K.; Caliari, S.R.; Weisgerber, D.W.; Harley, B.A.
Cell Tissue Res. 2015, 362, 633-642.
Ilin, Y.; Choi, J.S.; Harley, B.A.; Kraft, M.L.
Anal. Chem. 2015, 87, 11317-11324.
Garcia De Gonzalo, C.V.; Denham, E.L.; Mars, R.A.; Stulke, J.; van der Donk, W.A.; van Dijl, J.M.
Antimicrob. Agents Chemother. 2015, 59, 6844-6854.
Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging
Smith, C.E.; Ernenwein, D.; Shkumatov, A.; Clay, N.E.; Lee, J.; Melhem, M.; Misra, S.; Zimmerman, S.C.; Kong, H.
Biomaterials 2015, 69, 184-190.
Genetic, Genomic, and Transcriptomic Studies of Pyruvate Metabolism in Methanosarcina barkeri Fusaro
Lopez Munoz, M.M.; Schoneit, P.; Metcalf, W.W.
J. Bacteriol. 2015, 197, 3592-3600.
Chakraborty, S.; Polen, M.J.; Chacon, K.N.; Wilson, T.D.; Yu, Y.; Reed, J.; Nilges, M.J.; Blackburn, N.J.; Lu, Y.
Biochemistry 2015, 54, 6071-6081.
Chakraborty, S.; Reed, J.; Sage, J.T.; Branagan, N.C.; Petrick, I.D.; Miner, K.D.; Hu, M.Y.; Zhao, J.; Alp, E.E.; Lu, Y.
Inorg. Chem. 2015, 54, 9317-9329.
Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells
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Anal. Methods 2015, 7, 7095-7105.
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Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family
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Nat. Commun. 2015, 6, 6947.
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G3 (Bethesda) 2015, 5, 719-740.
Mineralized collagen scaffolds induce hMSC osteogenesis and matrix remodeling
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PLoS Genet. 2015, 11, e1004977.
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Ortega, M.A.; Hao, Y.; Zhang, Q.; Walker, M.C.; van der Donk, W.A.; Nair, S.K.
Nature 2015, 517. 509-512.
Caliari, S.R.; Gonnerman, E.A.; Grier, W.K.; Weisgerber, D.W.; Banks, J.M.; Alsop, A.J.; Lee, J.S.; Bailey, R.C.; Harley, B.A.
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2014
Chekan, J.R.; Kwon, I.H.; Agarwal, V.; Dodd, D.; Revindran, V.; Mackie, R.I.; Cann, I.; Nair, S.K.
J. Biol. Chem. 2014, 289, 34965-34977.
Changing the peptide specificity of a human T-cell receptor by directed evolution
Smith, S.N.; Wang, Y.; Baylon, J.L.; Singh, N.K.; Baker, B.M.; Tajkhorshid, E.; Kranz, D.M.
Nat. Commun. 2014, 5, 5223.
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Ortega, M.A.; Hao, Y.; Zhang, Q.; Walker, M.C.; van der Donk, W.A.; Nair, S.K.
Nature 2015, 517, 509-512.
Brothers, M.C.; Geissler, B.; Hisao, G.S.; Wilson, B.A.; Satchell, K.J.; Rienstra, C.M.
Biomol. NMR Assign. 2014, 8, 225-228.
Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis
Dunbar, K.L.; Chekan, J.R.; Cox, C.L.; Burkhart, B.J.; Nair, S.K.; Mitchell, D.A.
Nat. Chem. Biol. 2014, 10, 823-829.
Caliari, S.R.; Harley, B.A.
Tissue Eng. Part. A. 2014, 20, 2463-2472.
A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains
Dokukin, V.; Silverman, S.K.
Chem. Commun. 2014, 50, 9317-9320.
Zhang, Q.; Ortega, M.; Shi, Y.; Wang, H.; Melby, J.O.; Tang, W.; Mitchell, D.A.; van der Donk, W.A.
Proc. Natl. Acad. Sci. USA 2014, 111, 12031-12036.
DNA-catalyzed lysine side chain modification
Brandsen, B.M.; Velez, T.E.; Sachdeva, A.; Ibrahim, N.A.; Silverman, S.K.
Angew. Chem. Int. Ed. 2014, 53, 9045-9050.
Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO
Ortega, M.A.; Velásquez, J.E.; Garg, N.; Zhang, Q.; Joyce, R.E.; Nair, S.K.; van der Donk, W.A.
ACS Chem. Biol. 2014, 9, 1718-1725.
Caliari, S.R.; Harley, B.A.
Adv. Healthc. Mater. 2014, 3, 1086-1096.
π-π interaction energies as determinants of the photodimerization of mono-, di-, and triazastilbenes
Parent, A.A.; Ess, D.H.; Katzenellenbogen, J.A.
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Identifying the lineages of individual cells in cocultures by multivariate analysis of Raman spectra
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Analyst. 2014, 139, 2177-2185.
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Wang, Q.; Burles, K.; Couturier, B.; Randall, C.M.; Shisler, J.; Barry, M.
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Cross-linkable liposomes stabilize a magnetic resonance contrast-enhancing polymeric fastener
Smith, C.E.; Kong, H.
Langmuir. 2014, 30, 3697-3704.
Brothers, M.C.; Geissler, B.; Hisao, G.S.; Satchell, K.J.; Wilson, B.A.; Rienstra, C.M.
Biomol. NMR Assign. 2014, 8, 221-224.
Caliari, S.R.; Mozdzen, L.C.; Armitage, O.; Oyen, M.L.; Harley, B.A.
J. Biomed. Mater. Res. A. 2014, 102, 917-927.
NMR structure of the S-linked glycopeptide sublancin 168
Garcia De Gonzalo, C.V.; Zhu, L.; Oman, T.J.; van der Donk, W.A.
ACS Chem. Biol. 2014, 9, 796-801.
Chakraborty, S.; Reed, J.; Ross, M.; Nilges, M.J.; Petrik, I.D.; Ghosh, S.; Hammes-Schiffer, S.; Sage, J.T.; Zhang, Y.; Schulz, C.E.; Lu, Y.
Angew. Chem. Int. Ed. 2014, 53, 2417-2421.
Botham, R.C.; Fan, T.M.; Im, I.; Borst, L.B.; Dirikolu, L.; Hergenrother, P.J.
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Biochemistry 2014, 53, 188-201.
The extracellular protein VlsE is destabilized inside cells
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Wang, H.; Oman, T.J.; Zhang, R.; Garcia De Gonzalo, C.V.; Zhang, Q.; van der Donk, W.A.
J. Am. Chem. Soc. 2014, 136, 84-87.
Mode of action and structure-activity relationship studies of geobacillin I
Garg, N.; Oman, T.J.; Andrew Wang, T.S.; De Gonzalo, C.V.; Walker, S.; van der Donk, W.A.
J. Antibiot. 2014, 67, 133-136.
2013
Weisgerber, D.W.; Kelkhoff, D.O.; Caliari, S.R.; Harley, B.A.
J. Mech. Behav. Biomed. Mater. 2013, 28, 26-36.
Smith, C.E.; Shkumatov, A.; Withers, S.G.; Yang, B.; Glockner, J.F.; Misra, S.; Roy, E.J.; Wong, C.H.; Zimmerman, S.C.; Kong, H.
ACS Nano. 2013, 7, 9599-9610.
Bai, L.; Livnat, I.; Romanova, E.V.; Alexeeva, V.; Yau, P.M.; Vilim, F.S.; Weiss, K.R.; Jing, J.; Sweedler, J.V.
J. Biol. Chem. 2013, 288, 32837-32851.
Smith, S.N.; Sommermeyer, D.; Piepenbrink, K.H.; Blevins, S.J.; Bernhard, H.; Uckert, W.; Baker, B.M.; Kranz, D.M.
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DNA-catalyzed hydrolysis of esters and aromatic amides
Brandsen, B.M.; Hesser, A.R.; Castner, M.A.; Chandra, M.; Silverman, S.K.
J. Am. Chem. Soc. 2013, 135, 16014-16017.
DNA catalysts with tyrosine kinase activity
Walsh, S.M.; Sachdeva, A.; Silverman, S.K.
J. Am. Chem. Soc. 2013, 135, 14928-14931.
A liposome-based ion release impedance sensor for biological detection
Damhorst, G.L.; Smith, C.E.; Salm, E.M.; Sobieraj, M.M.; Ni, H.; Kong, H.; Bashir, R.
Biomed. Microdevices 2013, 15, 895-905.
Directed Evolution: Past, Present and Future
Cobb, R.E.; Chao, R.; Zhao, H.
AIChE J. 2013, 59, 1432-1440.
Sphingolipid domains in the plasma membranes of fibroblasts are not enriched with cholesterol
Frisz, J.F.; Klitzing, H.A.; Lou, K.; Hutcheon, I.D.; Weber, P.K.; Zimmerberg, J.; Kraft, M.L.
J. Biol. Chem. 2013, 288, 16855-16861.
Caliari, S.R.; Harley, B.A.
Tissue Eng. Part A. 2013, 19, 1100-1112.
Directed evolution as a powerful synthetic biology tool
Cobb, R.E.; Sun, N.; Zhao, H.
Methods 2013, 60, 81-90.
Huigens, R.W. 3rd; Morrison, K.C.; Hicklin, R.W.; Flood, T.A. Jr.; Richter, M.F.; Hergenrother, P.J.
Nat. Chem. 2013, 5, 195-202.
Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts
Frisz, J.F.; Lou, K.; Klitzing, H.A.; Hanafin, W.P.; Lizunov, V.; Wilson, R.L.; Carpenter, K.J.; Kim, R.; Hutcheon, I.D.; Zimmerberg, J.; Weber, P.K.; Kraft, M.L.
Proc. Natl. Acad. Sci. USA 2013, 110, E613-E622.
2012
Lanthanide ions as required cofactors for DNA catalysts
Dokukin, V.; Silverman, S.K.
Chem. Sci. 2012, 3, 1707-1714.
Evolution of lanthipeptide synthetases
Zhang, Q.; Yu, Y.; Vélasquez, J.E.; van der Donk, W.A.
Proc. Natl. Acad. Sci. USA 2012, 109, 18361-18366.
Peck, S.C.; Kim, S.Y.; Evans, B.S.; van der Donk, W.A.
Medchemcomm. 2012, 3, 967-970.
Caliari, S.R.; Weisgerber, D.W.; Ramirez, M.A.; Kelkhoff, D.O.; Harley, B.A.
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Frisz, J.F.; Choi, J.S.; Wilson, R.L.; Harley, B.A.; Kraft, M.L.
Anal. Chem. 2012, 84, 4307-4313.
Differential effects of procaspase-3 activating compounds in the induction of cancer cell death
West, D.C.; Qin, Y.; Peterson, Q.P.; Thomas, D.L.; Palchaudhuri, R.; Morrison, K.C.; Lucas, P.W.; Palmer, A.E.; Fan, T.M.; Hergenrother, PJ.
Mol. Pharm. 2012, 9, 1425-1434.
YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations
Dunbar, K.L.; Melby, J.O.; Mitchell, D.A.
Nat. Chem. Biol. 2012, 8, 569-575.
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Bioconjug. Chem. 2012, 23, 450-460.
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Covalent tagging of phosphorylated peptides by phosphate-specific deoxyribozymes
Sachdeva. A.; Chandra, M.; Chandrasekar, J.; Silverman, S.K.
Chembiochem 2012, 13, 654-657.
Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG)
Finch, K.E.; Knezevic, C.E.; Nottbohm, A.C.; Partlow, K.C.; Hergenrother, P.J.
ACS Chem. Biol. 2012, 7, 563-570.
Randall, C.M.; Jokela, J.A.; Shisler, J.L.
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ACS Comb. Sci. 2012, 14, 44-50.
Sachdeva, A.; Silverman, S.K.
Org. Biomol. Chem. 2012, 10, 122-125.
Brothers, M.C.; Nesbitt, A.E.; Hallock, M.J.; Rupasinghe, S.G.; Tang, M.; Harris, J.; Baudry, J.; Schuler, M.A.; Rienstra, C.M.
J. Biomol. NMR 2012, 52, 41-56.
Discovery and biosynthesis of phosphonate and phosphinate natural products
Peck. S.C.; Gao, J.; van der Donk, W.A.
Methods Enzymol. 2012, 516, 101-123.
2011
Molohon, K.J.; Melby, J.O.; Lee, J.; Evans, B.S.; Dunbar, K.L.; Bumpus, S.B.; Kelleher, N.L.; Mitchell, D.A.
ACS Chem. Biol. 2011, 6, 1307-1313.
The development of collagen-GAG scaffold-membrane composites for tendon tissue engineering
Caliari, S.R.; Ramirez, M.A.; Harley, B.A.
Biomaterials 2011, 32, 8990-8998.
Bae, B.; Cobb, R.E.; DeSieno, M.A.; Zhao, H.; Nair, S.K.
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Invest New Drugs 2011, 29, 901-911.
Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ
DeSieno, M.A.; van der Donk, W.A.; Zhao, H.
Chem. Commun. 2011, 47, 10025-10027.
A complex lipoate utilization pathway in Listeria monocytogenes
Christensen, Q.H.; Hagar, J.A.; O'Riordan, M.X.; Cronan, J.E.
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ACS Appl. Mater. Interfaces 2011, 3, 3762-3771.
Nine post-translational modifications during the biosynthesis of cinnamycin
Ökesli, A.; Cooper, L.E.; Fogle, E.J.; van der Donk, W.A.
J. Am. Chem. Soc. 2011, 133, 13753-13760.
Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase
Peck, S.C.; Cooke, H.A.; Cicchillo, R.M.; Malova, P.; Hammerschmidt, F.; Nair, S.K.; van der Donk, W.A.
Biochemistry 2011, 50, 6598-6605.
Caliari, S.R.; Harley, B.A.
Biomaterials 2011, 32, 5330-5340.
Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate
Velásquez, J.E.; Zhang, X.; van der Donk, W.A.
Chem. Biol. 2011, 18, 857-867.
Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin
Knerr, P.J.; Tzekou, A.; Ricklin, D.; Qu, H.; Chen, H.; van der Donk, W.A.; Lambris, J.D.
ACS Chem. Biol. 2011, 6, 753-760.
Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin
Gut, I.M.; Blanke, S.R.; van der Donk, W.A.
ACS Chem. Biol. 2011, 6, 744-752.
Circello, B.T.; Miller, C.G.; Lee, J.H.; van der Donk, W.A.; Metcalf, W.W.
Antimicrob. Agents Chemother. 2011, 55, 3357-3362.
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Integr. Biol. 2011, 3, 779-791.
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Biomaterials 2011, 32, 3949-3957.
Bertini, S.; De Cupertinis, A.; Granchi, C.; Bargagli, B.; Tuccinardi, T.; Martinelli, A.; Macchia, M.; Gunther, J.R.; Carlson, K.E.; Katzenellenbogen, J.A.; Minutolo, F.
Eur. J. Med. Chem. 2011, 46, 2453-2462.
Jeyakumar, M.; Carlson, K.E.; Gunther, J.R.; Katzenellenbogen, J.A.
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A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis
Christensen, Q.H.; Martin, N.; Mansilla, M.C.; de Mendoza, D.; Cronan, J.E.
Mol. Microbiol. 2011, 80, 350-363.
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On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase
Whitteck, J.T.; Malova, P.; Peck, S.C.; Cicchillo, R.M.; Hammerschmidt, F.; van der Donk, W.A.
J. Am. Chem. Soc. 2011, 133, 4236-4239.
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BMC Microbiol. 2011, 11, 46.
Genome mining for ribosomally synthesized natural products
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Curr. Opin. Chem. Biol. 2011, 15, 11-21.
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PLoS One 2011, 6, e26903.
2010
Christensen, Q.H.; Cronan, J.E.
Biochemistry 2010, 49, 10024-10036.
Moore, T.W.; Gunther, J.R.; Katzenellenbogen, J.A.
Bioconjug. Chem. 2010, 21, 1880-1889.
Lee, J.H.; Bae, B.; Kuemin, M.; Circello, B.T.; Metcalf, W.W.; Nair, S.K.; van der Donk, W.A.
Proc. Natl. Acad. Sci. USA 2010, 107, 17557-17562.
Direct, Electrocatalytic Oxygen Reduction by Laccase on Anthracene-2-methanethiol Modified Gold
Thorum, M.S.; Anderson, C.A.; Hatch, J.J.; Campbell, A.S.; Marshall, N.M.; Zimmerman, S.C.; Lu, Y.; Gewirth, A.A.
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Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound
Peterson, Q.P.; Hsu, D.C.; Novotny, C.J.; West, D.C.; Kim, D.; Schmit, J.M.; Dirikolu, L.; Hergenrother, P.J.; Fan, T.M.
Cancer Res. 2010, 70, 7232-7241.
General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates
Dick, G.R.; Knapp, D. M.; Gillis, E.P.; Burke, M.D.
Org. Lett. 2010, 12, 2314-2317.
Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster
Circello, B.T.; Eliot, A.C.; Lee, J.H.; van der Donk, W.A.; Metcalf, W.W.
Chem. Biol. 2010, 17, 402-411.
Exit strategies for charged tRNA from GluRS
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DNA-catalyzed serine side chain reactivity and selectivity
Sachdeva, A.; Silverman, S.K.
Chem. Commun. 2010, 46, 2215-2217.
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Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis
Peterson, Q.P.; Goode, D.R.; West, D.C.; Botham, R.C.; Hergenrother, P.J.
Nat. Protoc. 2010, 5, 294-302.
Deciphering the late biosynthetic steps of antimalarial compound FR-900098
Johannes, T.W.; DeSieno, M.A.; Griffin, B.M.; Thomas, P.M.; Kelleher, N.L.; Metcalf, W.W.; Zhao, H.
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2009
Synthesis of biphenyl proteomimetics as estrogen receptor-α coactivator binding inhibitors
Williams, A.B.; Weiser, P.T.; Hanson, R.N.; Gunther, J.R.; Katzenellenbogen, J.A.
Org. Lett. 2009, 11, 5370-5373.
Rationally tuning the reduction potential of a single cupredoxin beyond the natural range
Marshall, N.M.; Garner, D.K.; Wilson, T.D.; Gao, Y.G.; Robinson, H.; Nilges, M.J.; Lu, Y.
Nature 2009, 462, 113-116.
DNA-catalyzed sequence-specific hydrolysis of DNA
Chandra, M.; Sachdeva, A.; Silverman, S.K.
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ACS Chem. Biol. 2009, 4, 435-440.
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition
Peterson, Q.P.; Goode, D.R.; West, D.C.; Ramsey, K.N.; Lee, J.J.; Hergenrother, P.J.
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2008
Inhibition of Bacillus anthracis spore outgrowth by nisin
Gut, I.M.; Prouty, A.M.; Ballard, J.D.; van der Donk, W.A.; Blanke, S.R.
Antimicrob. Agents Chemother. 2008, 52, 4281-4288.
LaFrate, A.L.; Gunther, J.R.; Carlson, K.E.; Katzenellenbogen, J.A.
Bioorg. Med. Chem. 2008, 16, 10075-10084.
Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner
Kim, S.H,; Gunther, J.R.; Katzenellenbogen, J.A.
Org. Lett. 2008, 10, 4931-4934.
Parent, A.A.; Gunther, J.R.; Katzenellenbogen, J.A.
J. Med. Chem. 2008, 51, 6512-6530.
Structure-activity relationship studies of the two-component lantibiotic haloduracin
Cooper, L.E.; McClerren, A.L.; Chary, A.; van der Donk, W.A.
Chem. Biol. 2008, 15, 1035-1045.
Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase
Rakus, J.F.; Fedorov, A.A.; Fedorov, E.V.; Glasner, M.E.; Hubbard, B.K.; Delli, J.D.; Babbitt, P.C.; Almo, S.C.; Gerlt, J.A.
Biochemistry 2008, 47, 9944-9954.
Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line
Magarvey, N.A.; Fortin, P.D.; Thomas, P.M.; Kelleher, N.L.; Walsh, C.T.
ACS Chem. Biol. 2008, 3, 542-554.
Eliot, A.C.; Griffin, B.M.; Thomas, P.M.; Johannes, T.W.; Kelleher, N.L.; Zhao, H.; Metcalf, W.W.
Chem. Biol. 2008, 15, 765-770.
Shao, Z.; Blodgett, J.A.; Circello, B.T.; Eliot, A.C.; Woodyer, R.; Li, G.; van der Donk, W.A.; Metcalf, W.W.; Zhao, H.
J. Biol. Chem. 2008, 283, 23161-23168.
The importance of the leader sequence for directing lanthionine formation in lacticin 481
Patton, G.C.; Paul, M.; Cooper, L.E.; Chatterjee, C.; van der Donk, W.A.
Biochemistry 2008, 47, 7342-7351.
Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction
Gunther, J.R.; Moore, T.W.; Collins, M.L.; Katzenellenbogen, J.A.
ACS Chem. Biol. 2008, 3, 282-286.
Dynamics of Recognition between tRNA and elongation factor Tu
Eargle, J.; Black, A.A.; Sethi, A.; Trabuco, L.G.; Luthey-Schulten, Z.
J. Mol. Biol. 2008, 377, 1382-1405.
Deconstruction of iterative multidomain polyketide synthase function
Crawford, J.M.; Thomas, P.M.; Scheerer, J.R.; Vagstad, A.L.; Kelleher, N.L.; Townsend, C.A.
Science 2008, 320, 243-246.
2007
Rakus, J.F.; Fedorov, A.A.; Fedorov, E.V.; Glasner, M.E.; Vick, J.E.; Babbitt, P.C.; Almo, S.C.; Gerlt, J.A.
Biochemistry 2007, 46, 12896-12908.
Parks, B.A.; Jiang, L.; Thomas, P.M.; Wenger, C.D.; Roth, M.J.; Boyne, M.T. 2nd; Burke, P.V.; Kwast, K.E.; Kelleher, N.L.
Anal. Chem. 2007, 79, 7984-7991.
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide
Blodgett, J.A.; Thomas, P.M.; Li, G.; Velasquez, J.E.; van der Donk, W.A.; Kelleher, N.L.; Metcalf, W.W.
Nat. Chem. Biol. 2007, 3, 480-485.
Whitteck, J.T.; Ni, W.; Griffin, B.M.; Eliot, A.C.; Thomas, P.M.; Kelleher, N.L.; Metcalf, W.W.; van der Donk, W.A.
Angew. Chem. Int. Ed. 2007, 46, 9089-9092.
2006
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster
Woodyer, R.D.; Shao, Z.; Thomas, P.M.; Kelleher, N.L.; Blodgett, J.A.; Metcalf, W.W.; van der Donk, W.A.; Zhao, H.
Chem. Biol. 2006, 13, 1171-1182.