Kai Gui

Alzheimer’s disease is a complex neurodegenerative condition with limited therapeutic options. Recent developments for new treatments have focused on targeting amyloid beta peptide aggregation, but this strategy has shown little success in clinical trials. New potential therapeutic targets are emerging, including hyperphosphorylated tau protein, metal dyshomeostasis, oxidative stress, neuroinflammation and mitochondrial dysfunction. My research involves the design and synthesis of novel multi-functional compounds, chemical agents that target multiple hallmarks of Alzheimer’s disease for therapeutic and diagnostic purposes. Molecules that modulate mitochondria health, an understudied therapeutic target, are of special interest to my research